What are The Differences between NKC and DCC?

ADCC

Cells Capable of Cytotoxicity Express Fc Receptors

Antibody Binds Target Cell, Cytotoxic Cells Bind Fc Portion Of Ab

Antibody Provides The Specificity

Examples Of Cells Capable Of ADCC

MF, NK, Neutrophils, eosinophils

Killing Of Target Is Accomplished

Thru perforin, granzyme (NK, Eosinophils)

TNF (MF, NK)

Lytic enzymes (MF, Neutrophils, Eosinophils, NK)

NKC

Natural Killer cells (NK lymphocytes)

Small, distinct group of large granular lymphocytes

Nonspecific killers which respond to the lack of self-antigens and to the presence of specific sugars before the antigen-specific immune system is activated

Able to kill virus-infected body cells and some tumor cells by releasing various defensive molecules (perforin and granzymes) – not by phagocytosis

Secrete potent chemicals that enhance the