What are
the differences between pseudotypes and Pseudovirions?
Pseudotypes:
•
This happens during mixed viral infections
•
During replication in co-infected cells,
•
the genome of one virus may become encapsidated in the
heterologous protein coat encoded by the second virus
Pseudovirions
·
During viral replication the capsid sometimes encloses
host nucleic acid rather than viral nucleic acid.
·
Such particles look like ordinary virus particles when
observed by EM, but do not replicate.
All animal
viruses helical nucleocapsids are wound into a coil and enclosed within a
lipoprotein envelope.
What is
the envelope composed of?
•
Matrix protein - viral specific
•
lipid bilayer - from host cell
•
glycoprotein coat virus specific
What is
important about the maxtrix protein?
•
It is the inner layer of the envelope
•
It is viral-specified
•
serves as a recognition site for the nucleocapsid at the
plasma membrane
•
provides added rigidity to the envelope
What is
important about the lipid bilayer?
•
Comes from the host cell
•
it is the middle layer of the envelope
What is
important in the glycoprotein layer?
•
Outer layer of envelope
•
contains projecting peplomers which are virus-specified
•
important immunogens
Where do
viral carbohydrates come from and what are they used for?
•
They are host cell derived
•
They are found associated with virus specified proteins
•
They form glycoprotein outer layer of the envelope
How does
the envelope affect the infectivity of most enveloped viruses?
•
The envelope contains attachment sites.
•
The integrity of the envelope is essential for
infectivity in most viruses
Which virus
possesses a viral envelope that is not necessary for infectivity?
•
Poxvirus
No comments:
Post a Comment